If drops were given directly to the baby, the acid in the upper digestive tract would quickly change the nature of the enzyme and render Colief® ineffective. However, mixing 4 drops of Colief® with a little expressed foremilk* appears to protect the active ingredient, lactase enzyme. The foremilk preparation provides a lining to the baby’s upper digestive tract, mixing with the breast milk and working to reduce the lactose level of the milk.
We believe that in this form, the enzyme has an effective “working life” of approximately 30 minutes. Laboratory trials have shown that 4 drops of Colief® in 3.38 fl oz of infant milk at body temperature will break down approximately 70% of the lactose in 30 minutes.
* Foremilk contains a concentration of the lactose in breast milk.